![]() ![]() ![]() 2, 3, 5, 7 Increased dead space is independently associated with an increased risk of death in subjects with ARDS. 1– 6 The Enghoff equation is influenced by large shunt fractions present in ARDS, and the result is a good global index of the efficiency of lung gas exchange. In critical care, the most common approach to measuring V D/V T is volumetric capnography, which reports CO 2 elimination as a function of expired V T, and V D/V T is calculated using the Enghoff modification of Bohr's equation: V D/V T = (P aCO 2 − P ̄ECO 2)/P aCO 2, where P aCO 2 is the partial pressure of CO 2 in arterial blood and P ̄ECO 2 is a measure or an estimate of mixed-expired partial pressure of CO 2. Physiologic dead space (V D), which is defined as the fraction of tidal volume (V T) that does not participate in gas exchange, provides information about the efficiency of lung gas exchange. ![]()
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